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KMID : 0882420140860020247
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Korean Journal of Medicine
2014 Volume.86 No. 2 p.247 ~ p.252
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A Case of Etoposide Therapy in a Patient Newly Diagnosed with Classic Kaposi’s Sarcoma and Rheumatoid Arthritis
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Choi Nan-Young
Park Seung-Ah
Han Bo-Ram
Kim Ho-Young
Min Soo-Kee
Kim Hyo-Jung
Zang Dae-Young
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Abstract
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Kaposi’s sarcoma typically occurs in immunocompromised patients, especially those with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) and human immunodeficiency virus (HIV) may play important roles in the development of Kaposi’s sarcoma. We report the case of a 75-year-old male who presented with progressive multiple purplish papules and nodules on the skin for 3 months. Social and past medical histories seemed incompatible with an immunesuppressed condition and tests for HIV antibodies and HHV-8 were negative. He was newly diagnosed with rheumatoid arthritis, according to the 2010 ACR-EULAR criteria. Typical findings of Kaposi’s sarcoma were confirmed by biopsy. After treatment with metronomic oral etoposide 25 mg once daily for 9 months, the skin lesions had almost resolved with no serious complication. Thus, we report a rare case of Kaposi’s sarcoma developing in a patient with newly diagnosed rheumatoid arthritis who showed a good response to oral etoposide.
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KEYWORD
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HIV, Sarcoma, Kaposi, Herpesvirus 8, Human, Etoposide, Arthritis, Rheumatoid
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